Randomized controlled clinical trials play an important role in the development of new medical therapies. There is, however, an ethical issue surrounding the use of randomized treatment allocation when the patient is suffering from a life threatening condition and requires immediate treatment. Such patients can only benefit from the treatment they actually receive and not from the alternative therapy, even if it ultimately proves to be superior. We discuss a novel new way to analyse data from such clinical trials based (...) on the use of the recently developed theory of imprecise probabilities. This work draws an explicit distinction between the related but nevertheless distinct questions of inference and decision in clinical trials. The traditional question of scientific interest asks 'Which treatment offers the greater chance of success?' and is the primary reason for conducting the clinical trial. The question of decision concerns the welfare of the patients in the clinical trial, asking whether the accumulated evidence favours one treatment over the other to such an extent that the next patient should decline randomization and instead express a preference for one treatment. Consideration of the decision question within the framework of imprecise probabilities leads to a mathematical definition of equipoise and a method for governing the randomization protocol of a clinical trial. This paper describes in detail the protocol for the conduct of clinical trials based on this new method of analysis, which is illustrated in a retrospective analysis of data from a clinical trial comparing the anti-emetic drugs ondansetron and droperidol in the treatment of postoperative nausea and vomiting. The proposed methodology is compared quantitatively using computer simulation studies with conventional clinical trial designs and is shown to maintain high statistical power with reduced sample sizes, at the expense of a high type I error rate that we argue is irrelevant in some specific circumstances. Particular emphasis is placed on describing the type of medical conditions and treatment comparisons where the new methodology is expected to provide the greatest benefit. (shrink)

Barnhardt, in “Dissociation: An Evolutionary Interpretation,” makes a case for understanding multiple personality as a “natural”phenomenon resulting from human biological evolution. He also argues that the reason that “multiple personalities” are not encountered more frequently is a result of a social construction encouraging “single” personalities. He concludes that it is from the interaction between the two that ethics derive. In this response I offer an alternative hermeneutic, using memory as the interpretive key, and by introducing Ricoeur’s work on narrative. highlight (...) how Barnhardt’s argument limits us to a “scientific” understanding of MultiplePersonality and thus limits our ability to understand and enact a viable “ethic” of care. (shrink)

Beginning from the notion that self is constructed, contributors in Identity Landscapes: Contemplating Place and the Construction of Self are particularly interested in how relationships with place inform identity development. Locating identity inquiry in methodologies that encourage an explicit examination of self (e.g. autoethnography, self-study, autobiographical inquiry, a/r/tography, and reflexive inquiry), authors situate themselves epistemologically and geographically as they explore where place and identity converge. Through critical, qualitative, creative, and arts-integrated approaches, this collection aims to advance thought regarding the myriad (...) ways that place informs identity development. (shrink)

Genetic engineering is a social invention as much as a biological one. Ordinary citizens interested in the well-being of life on the planet should therefore be involved in the ethical debates concerning the future of nonhuman animals. The creations of genetic engineers ought to be evaluated on a case-by-case basis by what the American philosopher R. G. Frey calls Frey is an advocate for putting animals in perspective, which means that animals matter, but not as much as humans. He therefore (...) supports the prevailing moral orthodoxy, which currently in the West means that animals can be eaten, dissected, hunted, and exhibited, provided that these things are done humanely and that the benefits to humans outweigh the harms to the animals. The he suggests, would have no objection to humans killing animals as long as the animals do not suffer. In the present paper, my aim is to raise some of the ethical, welfare, and social issues from an animal-protectionist perspective which ordinary citizens would need to consider if they were ever asked to vote on the benefits or otherwise of the impact of genetic engineering on animal welfare. (shrink)

Offers an overview of work on the biology of language - what is sometimes called the "biolinguistic approach." This book focuses on the interplay between variation and the universal properties of language. It provides case studies from the areas of syntactic variation, genetic variation, neurological variation and historical variation.

The representation theorems of expected utility theory show that having certain types of preferences is both necessary and sufficient for being representable as having subjective probabilities. However, unless the expected utility framework is simply assumed, such preferences are also consistent with being representable as having degrees of belief that do not obey the laws of probability. This fact shows that being representable as having subjective probabilities is not necessarily the same as having subjective probabilities. Probabilism can be defended on the (...) basis of the representation theorems only if attributions of degrees of belief are understood either antirealistically or purely qualitatively, or if the representation theorems are supplemented by arguments based on other considerations (simplicity, consilience, and so on) that single out the representation of a person as having subjective probabilities as the only true representation of the mental state of any person whose preferences conform to the axioms of expected utility theory. (shrink)

This paper proposes the CorpRank algorithm to extract social hierarchies from electronic communication data. The algorithm computes a ranking score for each user as a weighted combination of the number of emails, the number of responses, average response time, clique scores, and several degree and centrality measures. The algorithm uses principal component analysis to calculate the weights of the features. This score ranks users according to their importance, and its output is used to reconstruct an organization chart. We illustrate the (...) algorithm over real-world data using the Enron corporation’s e-mail archive. Compared to the actual corporate work chart, compensation lists, judicial proceedings, and analyzing the major players involved, the results show promise. (shrink)

Through critical, qualitative, creative, and arts-integrated approaches, this collection aims to explore the co-curricular capacity of lived experience to re/humanize education.

The simulation hypothesis claims that the whole observable universe, including us, is a computer simulation implemented by technologically advanced beings for an unknown purpose. The simulation argument (as I reconstruct it) is an argument for this hypothesis with moderately plausible premises. I develop two lines of objection to the simulation argument. The first takes the form of a structurally similar argument for a conflicting conclusion, the claim that I am a so-called freak observer, formed spontaneously in a quantum or thermodynamic (...) fluctuation rather than through ordinary processes of evolution and growth. The second rejects the basic line of reasoning of both arguments: the sort of evidence they cite is not capable of supporting either the claim that I am a simulant or the claim that I am a freak observer. The evidence that simulants or freak observers exist is not a reason to think that I am one of them. (shrink)

Розкрито сутність поняття «рейтинг». Доведено значущість рейтингової оцінки для суб’єктів фінансового ринку, зокрема для страхових компаній, потенційних страхувальників, інвесторів та кредиторів.

Probabilistic coherence is not an absolute requirement of rationality; nevertheless, it is an ideal of rationality with substantive normative import. An idealized rational agent who avoided making implicit logical errors in forming his preferences would be coherent. In response to the challenge, recently made by epistemologists such as Foley and Plantinga, that appeals to ideal rationality render probabilism either irrelevant or implausible, I argue that idealized requirements can be normatively relevant even when the ideals are unattainable, so long as they (...) define a structure that links imperfect and perfect rationality in a way that enables us to make sense of the notion of better approximations to the ideal. I then analyze the notion of approximation to the ideal of coherence by developing a generalized theory of belief functions that allows for incoherence, and showing how such belief functions can be ordered with regard to greater or lesser coherence. (shrink)

This methodological discussion invites critical reflection about the procedures used to analyze the contribution of qualitative and mixed methods research to nursing trials by mounting an argument that these should rest on multiple publications produced about a project, rather than a single article. We illustrate the value‐added of this approach with findings from a qualitative, cross‐case analysis of three critical case exemplars from nursing researchers that each used a qualitative approach with a mixed method phase. The holistic lens afforded by (...) a case‐based approach informs nursing inquiry by documenting that the critical case exemplars presented evidence of (a) a sustained commitment of resources and expertise for the qualitative methods that extended across more than one phase of the trial, (b) the impact of the qualitative methods on the trial or its aftermath, (c) deploying a theoretical or conceptual framework for a variety of purposes, and (d) integrating qualitative and quantitative data for purposes of extending explanatory power. Findings challenge the practice of linking purposes served by qualitative and mixed methods to a single trial phase. (shrink)

Guides for the Journey is an introduction to the lives and thoughts of three significant thinkers: John Macmurray, Bernard Lonergan, and James Fowler. The book shows how their work is helpful in interpreting our lives and the world in which we live. Written for the introductory student or reader, this book makes Macmurray, Lonergan, and Fowler's work more accessible and is the first book to actually compare the thought of the three. Throughout the book, quotations from their writings help the (...) reader to absorb and appreciate the texture and meaning of their work. Readers are not presumed to be familiar with philosophy or the meaning of technical terms used. An index and a glossary of names and key terms provide easy reference tools. Endnotes and a bibliography will stimulate further reading on the subject. Guides for the Journey is highly appropriate for university courses in religion as well as religious workshops and lectures. Contents: List of Tables; Preface; Acknowledgments; Introduction; Endnotes; John Macmurray ; Endnotes; Macmurray's Characterization of the Personal Life; Endnotes; Bernard Lonergan; Endnotes; Lonergan's Understanding of Understanding; Endnotes; James Fowler ; Endnotes; Fowler's Faith Development Theory; Endnotes; A Summing Up; Endnotes; Glossary; Bibliography; Index. (shrink)

This book highlights some of the principles which should be considered by planners, legislative drafters, and policy-makers as they work to develop legal frameworks on access to genetic resources in their countries. Contextual information on the Convention on Biological Diversity and examples of how countries have approached the issue to date are provided.

Within the context of the study of the genetics of language, Chomskian laws of grammar, such as theStructure-dependence Condition and theA over A Condition, may be usefully regarded to have a status similar to that of Mendelian Laws in classical genetics. In both the case of Chomsky's Laws and Mendel's Laws, formal genetic principles are postulated which abstract away from the physical mechanisms involved and in both cases certain apparent counterexamples mirror a more complex underlying genetic organisation.

The digitization of society and academic research endeavours have led to an explosion of interest in the potential uses of population data in research. Alongside this, increasing attention is focussing on the conditions necessary for maintaining a social license for research practices. Previous research has pointed to the importance of demonstrating “public benefits” from research for maintaining public support, yet there has been very little consideration of what the term “public benefits” means or what public expectations of “public benefits” are. (...) In order to address this pressing issue a series of deliberative workshops with members of the public were held across Scotland in May and June 2017. The workshops aimed to engage a cross-section of the Scottish population in in-depth discussions of the ways that the public – or publics – might benefit from data-intensive health research. The findings reported here discuss workshop participants’ understandings and expectations of health research; who they considered to be “the public” that should benefit from health research and; in what ways they felt “the public” should benefit. Workshop participants’ preference was clearly for the widest possible public benefit to be felt by all, but they also acknowledged the value in research aiming to primarily benefit vulnerable groups within society. A key focus of discussions was the extent to which workshop participants were confident that potential public benefits would be realised. A crucial consideration then is the extent to which mechanisms and political support are in place to realise and maximise the public benefits of data-intensive health research. (shrink)

The quality of doctoral-level chemistry (N=145), computer science (N=58), geoscience (N=91), mathematics (N=115), physics (N=123), and statistics/biostatistics (N=64) programs at United States universities was assessed, using 16 measures. These measures focused on variables related to: program size; characteristics of graduates; reputational factors (scholarly quality of faculty, effectiveness of programs in educating research scholars/scientists, improvement in program quality during the last 5 years); university library size; research support; and publication records. Chapter I discusses prior attempts to assess quality in graduate education, (...) development of the study plans, and the selection of disciplines and programs to be evaluated. Chapter II discusses the methodology used, focusing on each of the assessment measures. Chapters III to VIII present, respectively, findings from the analyses of the chemistry, computer science, geoscience, mathematics, physics, and statistics/biostatistics programs. Chapter IX includes a summary of results, correlations among measures, several additional analyses, and suggestions for future studies. Among the findings reported are those indicating that mathematics programs had, on the average, the largest number of faculty (N=33) in December 1980 followed closely by physics (N=28) and chemistry (N=23), and that 80 percent of computer science students had job commitments by graduation. (Survey instruments and supporting documentation are included in appendices.) (JN). (shrink)

The quality of doctoral-level biochemistry (N=139), botany (N=83), cellular/molecular biology (N=89), microbiology (N=134), physiology (N=101), and zoology (N=70) programs at United States universities was assessed, using 16 measures. These measures focused on variables related to: (1) program size; (2) characteristics of graduates; (3) reputational factors (scholarly quality of faculty, effectiveness of programs in educating research scholars/scientists, improvement in program quality during the last 5 years); (4) university library size; (5) research support; and (6) publication records. Chapter I discusses prior attempts (...) to assess quality in graduate education, development of the study plans, and the selection of disciplines and programs to be evaluated. Chapter II discusses the methodology used, focusing on each of the assessment measures. Chapters III to VIII present, respectively, findings from the analyses of the biochemistry, botany, cellular/molecular biology, microbiology, physiology, and zoology programs. Chapter IX includes a summary of results, correlations among measures, several additional analyses, and suggestions for future studies. Among the findings reported are those indicating that cellular/molecular biology programs had, on the average, the largest number of faculty and that students in cellular/molecular biology, biology, biochemistry, microbiology, and physiology received a relatively high fraction of financial support. (Survey instruments and supporting documentation are included in appendices.) (JN). (shrink)

Australia's Coalition Against Duck Shooting sees duck-shooting as a social problem and as an injustice with moral, legal and environmental consequences. The small animal liberationist group has succeeded in dramatically reducing the numbers of duck shooters in Victoria, which is the home of duck-shooting in Australia. The Coalition's framing work with the public via the electronic media involves three parts: a diagnosis , a prognosis and a motivational frame , all of which construct hunting as a cruel, antisocial blood sport (...) that ought to be banned. In this article, television news bulletins and feature stories from the 1993 and 1994 campaigns are analyzed to show how CADS makes and sustains its claims. In addition to 90 pages of transcripts of news commentaries and descriptive accounts of the visuals, the data include tape-recorded interviews with some of the duck liberationists involved in the campaign. (shrink)